Ciprofloxacin

Composition :

Each tablet contains:
Ciprofloxacin (as ciprofloxacin HCl)               250 mg or 500 mg

Properties :

CIPROFLOXACIN is a f1uoroquinolone broad spectrum antibiotic, with bactericidal activity against a wide range of gram-negative and gram positive organisms.
Gram-negative: Enterobacteriaceae such as: E. coli. Klebsiella pneumoniae, Klebsiella oxytoca, Salmonella, Shigella, Proteus, Acinetobacter, H. influenzae, H. ducreyi, Neisseria gonormoeae, Neisseria meningitidis. MoraxeUa catarrhalis, Campylobacter, Brucella and Legionella pneumophila.
Gram-positive: Staph. aureus (methicillin-susceptible and methicillin -resistant strains), Staph. epidermidis, Staph. haemolylicus. Streptococcus pyogenes. Streptococcus pneumoniae.
Other organisms: Chlamydia trachomatis and Mycobacterium tuberculosis. After oral administration CIPROFLOXACIN is widely distributed throughout the body. Tissue concentration often exceeds serum concentration in both men and women, particular1y in genital tissue including the prostate.
CIPROFLOXACIN is present in active form in the saliva, nasal and
bronchial secretions, sputum, lymph. skin, blister fluid, peritoneal fluid, bile and prostatic secretions.
CIPROFLOXACIN has been also detected in lung, skin. fat. muscle,
cartilage, and bone. The drug diffuses into the cerebrospinal fluid: however, CSF concentrations are generally less than 10% of those found in serum. Low levels of the drug have been detected in the aqueous and vitreous humors of the eye.
CIPROFLOXACIN is eliminated principally by urinary excretion. but non-renal clearance may account for about a third of its elimination and includes hepatic metabolism, biliary excretion and possibly transluminal secretion across the intestinal mucosa.
CIPROFLOXACIN acts by inhibiting the A subunit of DNA gyrase
which is essential in the reproduction of bacterial DNA