Xilone

Xilone 5mg Syrup About Prednisolone Systemic synthetic Glucocorticoid, Immunosuppressant. Mechanism of Action of Prednisolone The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions. The drug exerts anti-inflammatory and immunosuppressant actions as follows: – 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukin Scientific Name: Prednislone sodium phosphate 5mg./5ml.

Drug Period: twice daily (every 12 hours)

Producing Company: EEPC ( Egyptian European Pharmaceutical Co.)